NNAT is a novel mediator of oxidative stress that suppresses ER + breast cancer.

ABSTRACT:

Background

Neuronatin (NNAT) was recently identified as a novel mediator of estrogen receptor-positive (ER+) breast cancer cell proliferation and migration, which correlated with decreased tumorigenic potential and prolonged patient survival. However, despite these observations, the molecular and pathophysiological role(s) of NNAT in ER + breast cancer remains unclear. Based on high protein homology with phospholamban, we hypothesized that NNAT mediates the homeostasis of intracellular calcium [Ca²⁺]_i levels and endoplasmic reticulum (EndoR) function, which is frequently disrupted in ER + breast cancer and other malignancies.

Methods

To evaluate the role of NNAT on [Ca²⁺]_i homeostasis, we used a combination of bioinformatics, gene

SUBMITTER: Plasterer C 

PROVIDER: S-EPMC10318825 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature