Potent anthelmintic activity of a colloidal nano-silver formulation (Silversol^®) against the model worm Caenorhabditis elegans.

ABSTRACT:

Objective

In the background of a very small number of effective anthelmintics available today with a narrow activity spectrum, and a rise in resistance against them among parasitic helminths, there is an urgent need for discovery of novel broad-spectrum anthelmintics displaying no or minimal toxicity towards the host. Silver being used since centuries for therapeutic purposes and considered safe for human consumption, we investigated anthelmintic activity of a colloidal nanosilver formulation Silversol®. Anthelmintic efficacy of the test formulation was assayed employing the nematode Caenorhabditis elegans as a model worm through a live-dead count.

Results

Silversol® exerted anthelmintic action superior to one of the positive controls (Benzimidazole), and almost at par to an

SUBMITTER: Gajera G 

PROVIDER: S-EPMC10318827 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature