Genetic Insights of Schizophrenia via Single Cell RNA-Sequencing Analyses.

ABSTRACT:

Background

Schizophrenia is a complex and heterogeneous disorder involving multiple regions and types of cells in the brain. Despite rapid progress made by genome-wide association studies (GWAS) of schizophrenia, the mechanisms of the illness underlying the GWAS significant loci remain less clear.

Study design

We investigated schizophrenia risk genes using summary-data-based Mendelian randomization based on single-cell sequencing data, and explored the types of brain cells involved in schizophrenia through the expression weighted cell-type enrichment analysis.

Results

We identified 54 schizophrenia risk genes (two-thirds of these genes were not identified using sequencing data of bulk tissues) using single-cell RNA-sequencing data. Further cell type enrichment analysi

SUBMITTER: Wu Y 

PROVIDER: S-EPMC10318862 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature