Cognitive Control System Gates Insula Processing of Affective Stimuli in Early Psychosis.

ABSTRACT:

Background and hypothesis

Impairments in the expression, experience, and recognition of emotion are common in early psychosis (EP). Computational accounts of psychosis suggest disrupted top-down modulation by the cognitive control system (CCS) on perceptual circuits underlies psychotic experiences, but their role in emotional deficits in EP is unknown.

Study design

The affective go/no-go task was used to probe inhibitory control during the presentation of calm or fearful faces in young persons with EP and matched controls. Computational modeling of functional magnetic resonance imaging (fMRI) data were performed using dynamic causal modeling (DCM). The influence of the CCS on perceptual and emotional systems was examined using parametric empirical bayes.

Study results

SUBMITTER: Koussis NC 

PROVIDER: S-EPMC10318863 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature