A Sex-Dependent Association Between Doxycycline Use and Development of Schizophrenia.

ABSTRACT:

Background

Doxycycline and minocycline are brain-penetrant tetracycline antibiotics, which recently gained interest because of their immunomodulatory and neuroprotective properties. Observational studies have suggested that exposure to these drugs may decrease the risk to develop schizophrenia, but results are inconsistent. The aim of this study was to investigate the potential association between doxycycline use and later onset of schizophrenia.

Design

We used data from 1 647 298 individuals born between 1980 and 2006 available through Danish population registers. 79 078 of those individuals were exposed to doxycycline, defined as redemption of at least 1 prescription. Survival analysis models stratified for sex with time-varying covariates were constructed to assess incide

SUBMITTER: de Witte LD 

PROVIDER: S-EPMC10318877 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature