Increased Prevalence of Rare Copy Number Variants in Treatment-Resistant Psychosis.

ABSTRACT:

Background

It remains unknown why ~30% of patients with psychotic disorders fail to respond to treatment. Previous genomic investigations of treatment-resistant psychosis have been inconclusive, but some evidence suggests a possible link between rare disease-associated copy number variants (CNVs) and worse clinical outcomes in schizophrenia. Here, we identified schizophrenia-associated CNVs in patients with treatment-resistant psychotic symptoms and then compared the prevalence of these CNVs to previously published schizophrenia cases not selected for treatment resistance.

Methods

CNVs were identified using chromosomal microarray (CMA) and whole exome sequencing (WES) in 509 patients with treatment-resistant psychosis (a lack of clinical response to ≥3 adequate antipsychotic

SUBMITTER: Farrell M 

PROVIDER: S-EPMC10318882 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature