Inflammatory bowel disease and prostate cancer risk: a two-sample Mendelian randomization analysis.

ABSTRACT:

Background

Previous epidemiological observational studies have reported an association between inflammatory bowel disease (IBD) and prostate cancer (PCa), but the causality is inconclusive. The purpose of this study was to evaluate the causality of IBD on PCa using the mendelian randomization (MR) analysis.

Methods

We performed a two-sample MR analysis with public genome-wide association studies (GWAS) data. Eligible instrumental variables (IVs) were selected according to the three assumptions of MR analysis. The inverse-variance weighted (IVW) method was the main method. Complementary methods included the MR-Egger regression, the Weighted Median, the Simple Mode, the Weighted Mode and MR pleiotropy residual sum and outlier (MR-PRESSO) methods.

Results

Genetically det

SUBMITTER: Cheng W 

PROVIDER: S-EPMC10318899 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature