Rare cases of Guillain-Barre syndrome after COVID-19 vaccination, Germany, December 2020 to August 2021.

ABSTRACT: BackgroundGuillain-Barré syndrome (GBS) has been associated with vaccination against COVID-19.AimWe aimed to compare clinical characteristics and analyse excess GBS cases following administration of different COVID-19 and influenza vaccines in Germany versus the expected numbers estimated from pre-pandemic background incidence rates.MethodsWe analysed safety surveillance data reported to the German national competent authority between 27 December 2020 and 31 August 2021. GBS cases were validated according to Brighton Collaboration (BC) criteria. We conducted observed vs expected (OvE) analyses on cases fulfilling BC criteria levels 1 to 4 for all four European Medicines Agency-approved COVID-19 vaccines and for influenza vaccines.ResultsA total of 214 GBS cases after COVID-19 vaccination h

SUBMITTER: Lehmann HC 

PROVIDER: S-EPMC10318936 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature