Dataset Information

Hospital admissions linked to SARS-CoV-2 infection in children and adolescents: cohort study of 3.2 million first ascertained infections in England.

ABSTRACT:

Objective

To describe hospital admissions associated with SARS-CoV-2 infection in children and adolescents.

Design

Cohort study of 3.2 million first ascertained SARS-CoV-2 infections using electronic health care record data.

Setting

England, July 2020 to February 2022.

Participants

About 12 million children and adolescents (age <18 years) who were resident in England.

Main outcome measures

Ascertainment of a first SARS-CoV-2 associated hospital admissions: due to SARS-CoV-2, with SARS-CoV-2 as a contributory factor, incidental to SARS-CoV-2 infection, and hospital acquired SARS-CoV-2.

Results

3 226 535 children and adolescents had a recorded first SARS-CoV-2 infection during the observation period, and 29 230 (0.9%) infections involved a SARS-CoV-2 associated hospital admission. The median length of stay was 2 (interquartile range 1-4) days) and 1710 of 29 230 (5.9%) SARS-CoV-2 associated admissions involved paediatric critical care. 70 deaths occurred in which covid-19 or paediatric inflammatory multisystem syndrome was listed as a cause, of which 55 (78.6%) were in participants with a SARS-CoV-2 associated hospital admission. SARS-CoV-2 was the cause or a contributory factor in 21 000 of 29 230 (71.8%) participants who were admitted to hospital and only 380 (1.3%) participants acquired infection as an inpatient and 7855 (26.9%) participants were admitted with incidental SARS-CoV-2 infection. Boys, younger children (<5 years), and those from ethnic minority groups or areas of high deprivation were more likely to be admitted to hospital (all P<0.001). The covid-19 vaccination programme in England has identified certain conditions as representing a higher risk of admission to hospital with SARS-CoV-2: 11 085 (37.9%) of participants admitted to hospital had evidence of such a condition, and a further 4765 (16.3%) of participants admitted to hospital had a medical or developmental health condition not included in the vaccination programme's list.

Conclusions

Most SARS-CoV-2 associated hospital admissions in children and adolescents in England were due to SARS-CoV-2 or SARS-CoV-2 was a contributory factor. These results should inform future public health initiatives and research.

SUBMITTER: Wilde H

PROVIDER: S-EPMC10318942 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Hospital admissions linked to SARS-CoV-2 infection in children and adolescents: cohort study of 3.2 million first ascertained infections in England.

Wilde Harrison H Tomlinson Christopher C Mateen Bilal A BA Selby David D Kanthimathinathan Hari Krishnan HK Ramnarayan Padmanabhan P Du Pre Pascale P Johnson Mae M Pathan Nazima N Pathan Nazima N Gonzalez-Izquierdo Arturo A Lai Alvina G AG Gurdasani Deepti D Pagel Christina C Denaxas Spiros S Vollmer Sebastian S Brown Katherine K

BMJ (Clinical research ed.) 20230705

<h4>Objective</h4>To describe hospital admissions associated with SARS-CoV-2 infection in children and adolescents.<h4>Design</h4>Cohort study of 3.2 million first ascertained SARS-CoV-2 infections using electronic health care record data.<h4>Setting</h4>England, July 2020 to February 2022.<h4>Participants</h4>About 12 million children and adolescents (age <18 years) who were resident in England.<h4>Main outcome measures</h4>Ascertainment of a first SARS-CoV-2 associated hospital admissions: due ...[more]

PMID: 37407076

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Dataset Information

Hospital admissions linked to SARS-CoV-2 infection in children and adolescents: cohort study of 3.2 million first ascertained infections in England.

Objective

Design

Setting

Participants

Main outcome measures

Results

Conclusions

Publications

Hospital admissions linked to SARS-CoV-2 infection in children and adolescents: cohort study of 3.2 million first ascertained infections in England.

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