Human gut bacteria tailor extracellular vesicle cargo for the breakdown of diet- and host-derived glycans.

ABSTRACT: Extracellular vesicles are produced in all three domains of life, and their biogenesis has common ancient origins in eukaryotes and archaea. Although bacterial vesicles were discovered several decades ago and multiple roles have been attributed to them, no mechanism has been established for vesicles biogenesis in bacteria. For this reason, there is a significant level of skepticism about the biological relevance of bacterial vesicles. Bacteroides thetaiotaomicron (Bt), a prominent member of the human intestinal microbiota, produces significant amounts of outer membrane vesicles (OMVs) which have been proposed to play key physiological roles. Here, we employed a dual marker system, consisting of outer membrane- and OMV-specific markers fused to fluorescent proteins to visualiz

SUBMITTER: Sartorio MG 

PROVIDER: S-EPMC10319031 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature