Effect of Two Years of Doxycycline Treatment on Infrarenal Aortic Neck Diameter.

ABSTRACT:

Objective

Endovascular aneurysm repair (EVAR) is a widely used option for patients with suitable vascular anatomy who have a large infrarenal abdominal aortic aneurysm (AAA). Neck diameter is the primary anatomical determinant of EVAR eligibility and device durability. Doxycycline has been proposed to stabilise the proximal neck after EVAR. This study explored doxycycline mediated aortic neck stabilisation in patients with small AAA, monitored by computed tomography over two years.

Methods

This was a multicentre prospective randomised clinical trial. Subjects from the Non-Invasive Treatment of Abdominal Aortic Aneurysm Clinical Trial (N-TA³CT, NCT01756833) were included in this secondary a priori analysis. Female baseline AAA maximum transverse diameter was

SUBMITTER: Panthofer AM 

PROVIDER: S-EPMC10319163 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature