NONHSAT098487.2 protects cardiomyocytes from oxidative stress injury by regulating the Notch pathway.

ABSTRACT: Acute myocardial infarction has increasingly become a global health problem and is a primary cause of cardiovascular disease-related death. Although long noncoding RNAs have been reported to play an important role in various cardiovascular diseases, their protective effects on cardiomyocytes against reactive oxygen species-induced oxidative injury have nonetheless been poorly studied. The present study aims to explore the effect of a novel long noncoding RNA, NONHSAT098487.2, on cardiomyocyte injury induced by H₂O₂. The expression of NONHSAT098487.2 and pathway-related genes was evaluated by quantitative real-time polymerase chain reaction. Cell viability, release of lactate dehydrogenase, and apoptosis levels were detected by cell counting kit-8, lactate dehydrogenas

SUBMITTER: Feng G 

PROVIDER: S-EPMC10319237 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature