Contribution of gut bacteria to arsenic metabolism in the first year of life in a prospective birth cohort.

ABSTRACT: Gut bacteria are at the interface of environmental exposures and their impact on human systems, and may alter host absorption, metabolism, and excretion of toxic chemicals. We investigated whether arsenic-metabolizing bacterial gene pathways related to urinary arsenic concentrations. In the New Hampshire Birth Cohort Study, urine and stool samples were obtained at six weeks (n = 186) and one year (n = 190) of age. Inorganic arsenic (iAs), monomethylarsonic acid (MMA), dimethylarsinic acid (DMA), and arsenobetaine (AsB) were quantified in infant urine samples using high-performance liquid chromatography with inductively coupled plasma mass spectrometry. Total arsenic exposure (tAs) was summarized as Σ(iAs, MMA, DMA) and log₂-transformed. Fecal microbial DNA underwent metagenomic

SUBMITTER: Laue HE 

PROVIDER: S-EPMC10319341 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature