Aerobic exercise reverses aging-induced depth-dependent decline in cerebral microcirculation.

ABSTRACT: Aging is a major risk factor for cognitive impairment. Aerobic exercise benefits brain function and may promote cognitive health in older adults. However, underlying biological mechanisms across cerebral gray and white matter are poorly understood. Selective vulnerability of the white matter to small vessel disease and a link between white matter health and cognitive function suggests a potential role for responses in deep cerebral microcirculation. Here, we tested whether aerobic exercise modulates cerebral microcirculatory changes induced by aging. To this end, we carried out a comprehensive quantitative examination of changes in cerebral microvascular physiology in cortical gray and subcortical white matter in mice (3-6 vs. 19-21 months old), and asked whether and how exercise may rescu

SUBMITTER: Shin P 

PROVIDER: S-EPMC10319437 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature