Facile Synthesis of Rapidly Degrading PEG-Based Thiol-Norbornene Hydrogels.

ABSTRACT: An alternate synthesis route was developed to prepare norbornene-functionalized poly(ethylene glycol) (PEG) from reacting multiarm PEG with carbic anhydride. The macromer, PEGNB_CA, permits photo-cross-linking of thiol-norbornene hydrogels with kinetics comparable to conventional PEGNB macromer. In addition, PEGNB_CA provides an additional carboxylate group for further conjugation with amine-bearing molecules. Interestingly, PEGNB_CA thiol-norbornene hydrogels are highly susceptible to hydrolytic degradation through enhanced ester hydrolysis. The ester linkage is further weakened after the secondary conjugation, resulting in extremely rapid degradation of PEGNB hydrogels. More importantly, the degradation can be readily adjusted via tuning macromer composition

SUBMITTER: Lin FY 

PROVIDER: S-EPMC10319469 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature