Evidence of causality of low body mass index on risk of adolescent idiopathic scoliosis: a Mendelian randomization study.

ABSTRACT:

Introduction

Adolescent idiopathic scoliosis (AIS) is a disorder with a three-dimensional spinal deformity and is a common disease affecting 1-5% of adolescents. AIS is also known as a complex disease involved in environmental and genetic factors. A relation between AIS and body mass index (BMI) has been epidemiologically and genetically suggested. However, the causal relationship between AIS and BMI remains to be elucidated.

Material and methods

Mendelian randomization (MR) analysis was performed using summary statistics from genome-wide association studies (GWASs) of AIS (Japanese cohort, 5,327 cases, 73,884 controls; US cohort: 1,468 cases, 20,158 controls) and BMI (Biobank Japan: 173430 individual; meta-analysis of genetic investigation of anthropometric traits and UK Bi

SUBMITTER: Otomo N 

PROVIDER: S-EPMC10319580 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature