A systematic review of the Woven EndoBridge device-do findings in pre-clinical animal models compare to clinical results?

ABSTRACT:

Background

The Woven Endobridge (WEB) is designed to treat intracranial wide-neck bifurcation aneurysms, preventing subarachnoid hemorrhage. The translational value of animal models used for WEB device testing is unknown. With this systematic review, we aim to identify the existing animal models used in testing the WEB device and compare the efficacy and safety outcomes to those of prospective clinical studies.

Methods

This study was funded by ZonMw: project number 114024133. A comprehensive search was performed in PubMed and in EMBASE via the Ovid interface. The following exclusion criteria were used: 1) not an original full-length research paper, 2) not an in vivo animal study or a human study, 3) no WEB implantation, 4) if in humans: not a prospective study. The SYRCLE ri

SUBMITTER: Aquarius R 

PROVIDER: S-EPMC10319665 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature