SFRP1 Expression is Inversely Associated With Metastasis Formation in Canine Mammary Tumours.

ABSTRACT:

Background

Canine mammary tumours (CMTs) are the most frequent tumours in intact female dogs and show strong similarities with human breast cancer. In contrast to the human disease there are no standardised diagnostic or prognostic biomarkers available to guide treatment. We recently identified a prognostic 18-gene RNA signature that could stratify human breast cancer patients into groups with significantly different risk of distant metastasis formation. Here, we assessed whether expression patterns of these RNAs were also associated with canine tumour progression.

Method

A sequential forward feature selection process was performed on a previously published microarray dataset of 27 CMTs with and without lymph node (LN) metastases to identify RNAs with significantly different

SUBMITTER: Seitz J 

PROVIDER: S-EPMC10319705 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature