Biocoordination reactions in copper(II) ions and phosphocholine systems including pyrimidine nucleosides and nucleotides.

ABSTRACT: The complexation reactions of phosphocholine and pyrimidine nucleosides as well as nucleotides with copper(II) ions were studied in the water system. Using potentiometric methods and computer calculations, the stability constants of the species were determined. Using spectroscopic methods such as UV-vis, EPR, ¹³C NMR, ³¹P NMR, FT-IR and CD, the coordination mode was established for complexes created in pH range 2.5-11.0. These studies will lead to a better understanding the role of copper(II) ions in living organisms and explain the interactions between them and the studied bioligands. The differences and similarities between nucleosides and nucleotides in the studied systems were also described, which testify to the significant influence of phosphate groups on the pr

SUBMITTER: Gabryel-Skrodzka M 

PROVIDER: S-EPMC10319719 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature