Dataset Information

Impact of Undernutrition on Tuberculosis Treatment Outcomes in India: A Multicenter, Prospective, Cohort Analysis.

ABSTRACT:

Background

Undernutrition is the leading risk factor for tuberculosis (TB) globally. Its impact on treatment outcomes is poorly defined.

Methods

We conducted a prospective cohort analysis of adults with drug-sensitive pulmonary TB at 5 sites from 2015-2019. Using multivariable Poisson regression, we assessed associations between unfavorable outcomes and nutritional status based on body mass index (BMI) nutritional status at treatment initiation, BMI prior to TB disease, stunting, and stagnant or declining BMI after 2 months of TB treatment. Unfavorable outcome was defined as a composite of treatment failure, death, or relapse within 6 months of treatment completion.

Results

Severe undernutrition (BMI <16 kg/m2) at treatment initiation and severe undernutrition before the onset of TB disease were both associated with unfavorable outcomes (adjusted incidence rate ratio [aIRR], 2.05; 95% confidence interval [CI], 1.42-2.91 and aIRR, 2.20; 95% CI, 1.16-3.94, respectively). Additionally, lack of BMI increase after treatment initiation was associated with increased unfavorable outcomes (aIRR, 1.81; 95% CI, 1.27-2.61). Severe stunting (height-for-age z score <-3) was associated with unfavorable outcomes (aIRR, 1.52; 95% CI, 1.00-2.24). Severe undernutrition at treatment initiation and lack of BMI increase during treatment were associated with a 4- and 5-fold higher rate of death, respectively.

Conclusions

Premorbid undernutrition, undernutrition at treatment initiation, lack of BMI increase after intensive therapy, and severe stunting are associated with unfavorable TB treatment outcomes. These data highlight the need to address this widely prevalent TB comorbidity. Nutritional assessment should be integrated into standard TB care.

SUBMITTER: Sinha P

PROVIDER: S-EPMC10319769 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature

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Publications

Impact of Undernutrition on Tuberculosis Treatment Outcomes in India: A Multicenter, Prospective, Cohort Analysis.

Sinha Pranay P Ponnuraja Chinnaiyan C Gupte Nikhil N Prakash Babu Senbagavalli S Cox Samyra R SR Sarkar Sonali S Mave Vidya V Paradkar Mandar M Cintron Chelsie C Govindarajan S S Kinikar Aarti A Priya Nadesan N Gaikwad Sanjay S Thangakunam Balamugesh B Devarajan Arutselvi A Dhanasekaran Mythili M Tornheim Jeffrey A JA Gupta Amita A Salgame Padmini P Christopher Devashyam Jesudas DJ Kornfeld Hardy H Viswanathan Vijay V Ellner Jerrold J JJ Horsburgh C Robert CR Gupte Akshay N AN Padmapriyadarsini Chandrasekaran C Hochberg Natasha S NS

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20230401 8

<h4>Background</h4>Undernutrition is the leading risk factor for tuberculosis (TB) globally. Its impact on treatment outcomes is poorly defined.<h4>Methods</h4>We conducted a prospective cohort analysis of adults with drug-sensitive pulmonary TB at 5 sites from 2015-2019. Using multivariable Poisson regression, we assessed associations between unfavorable outcomes and nutritional status based on body mass index (BMI) nutritional status at treatment initiation, BMI prior to TB disease, stunting, ...[more]

PMID: 36424864

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Dataset Information

Impact of Undernutrition on Tuberculosis Treatment Outcomes in India: A Multicenter, Prospective, Cohort Analysis.

Background

Methods

Results

Conclusions

Publications

Impact of Undernutrition on Tuberculosis Treatment Outcomes in India: A Multicenter, Prospective, Cohort Analysis.

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