Dynamic functional thalamocortical dysconnectivity in schizophrenia correlates to antipsychotics response.

ABSTRACT: Although many studies have showed abnormal thalamocortical networks in patients with schizophrenia (SCZ), the dynamic functional thalamocortical connectivity of individuals with SCZ and the effect of antipsychotics on this connectivity have not been investigated. Drug-naïve first-episode individuals with SCZ and healthy controls were recruited. Patients were treated with risperidone for 12 weeks. Resting-state functional magnetic resonance imaging was acquired at baseline and week 12. We identified six functional thalamic subdivisions. The sliding window strategy was used to determine the dynamic functional connectivity (dFC) of each functional thalamic subdivision. Individuals with SCZ displayed decreased or increased dFC variance in different thalamic subdivisions. The baseline dFC betwe

SUBMITTER: Yang M 

PROVIDER: S-EPMC10319786 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature