Biocompatible topical delivery system of high-molecular-weight hyaluronan into human stratum corneum using magnesium chloride.

ABSTRACT: Non-invasive delivery of hyaluronan into the stratum corneum (SC) is extremely difficult because of its high molecular weight and the strong barrier of the SC. We developed a safe method of administering hyaluronan into the human SC and determined its penetration route. The amount of hyaluronan that penetrated into the SC was 1.5-3 times higher in the presence of magnesium chloride hexahydrate (MgCl₂) than other metal chlorides. The root-mean-square radius of hyaluronan in water decreased with the addition of MgCl₂. Moreover, MgCl₂ solutions maintained their dissolved state on a plastic plate for a long time, suggesting that size compaction and inhibition of hyaluronan precipitation on the skin enhanced hyaluronan into the SC. Our results also strongly sugg

SUBMITTER: Fujii MY 

PROVIDER: S-EPMC10319798 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature