Atypical Hemolytic Uremic Syndrome Treated With Ravulizumab or Eculizumab: A Claims-Based Evaluation of Health Care Resource Utilization and Clinical Outcomes in the United States.

ABSTRACT:

Rationale and objective

Ravulizumab and eculizumab have shown efficacy for the treatment of atypical hemolytic uremic syndrome (aHUS), but real-world evidence for ravulizumab is limited owing to its more recent approval. This real-world database study examined outcomes for adult patients switching to ravulizumab from eculizumab and patients treated with individual treatments.

Study design

A retrospective, observational study using the Clarivate Real World Database.

Setting and population

US health-insurance billing data (January 2012 to March 2021) of patients aged 18 years or older with ≥1 diagnosis relevant to aHUS, ≥1 claim for treatment with eculizumab or ravulizumab, and no evidence of other indicated conditions.

Exposures

Treatment-switch (to ravulizumab

SUBMITTER: Wang Y 

PROVIDER: S-EPMC10319830 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature