The role of m⁶A demethylase FTO in chemotherapy resistance mediating acute myeloid leukemia relapse.

ABSTRACT: Acute myeloid leukemia (AML) is the most common hematopoietic malignancies, and chemotherapy resistance is one of the main causes of relapse. Because of lower survival rate for patients with relapse, it is pivotal to identify etiological factors responsible for chemo-resistance. In this work, direct MeRIP-seq analysis of sequential samples at stage of complete remission (CR) and relapse identifies that dysregulated N6-methyladenosine (m⁶A) methylation is involved in this progression, and hypomethylated RNAs are related to cell differentiation. m⁶A demethylase FTO is overexpressed in relapse samples, which enhances the drug resistance of AML cells in vivo and in vitro. In addition, FTO knockdown cells exhibit stronger capacity of differentiation towards granules and my

SUBMITTER: Zhang ZW 

PROVIDER: S-EPMC10319875 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature