NT-proBNP Reference Intervals in Healthy U.S. Children, Adolescents, and Adults.

ABSTRACT:

Background

N-terminal pro-B-type natriuretic peptide (NT-proBNP) is a cardiac biomarker used in the clinical management of heart failure. We sought to create updated reference intervals for NT-proBNP for healthy US children, adolescents, and adults.

Methods

We identified a population of healthy individuals using the 1999 to 2004 cycles of the National Health and Nutrition Examination Survey (NHANES). We measured serum NT-proBNP in 12 346 adults and 15 752 children and adolescents with the Elecsys NT-proBNP assay on the Roche e601 autoanalyzer. We compared 4 methods for reference interval calculation, and presented the final reference intervals using the robust method partitioned by age and sex categories.

Results

NT-proBNP values were available for 1949 healthy adults

SUBMITTER: Mu S 

PROVIDER: S-EPMC10320012 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature