Characterization of soluble TLR2 and CD14 levels during acute dengue virus infection.

ABSTRACT: Dengue virus infection results in a broad spectrum of diseases ranging from mild dengue fever (DF) to severe dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). Hitherto, there is no consensus biomarker for the prediction of severe dengue disease in patients. Yet, early identification of patients who progress to severe dengue is pivotal for better clinical management. We have recently reported that an increased frequency of classical (CD14 ⁺⁺CD16^-) monocytes with sustained high TLR2 expression in acutely infected dengue patients correlates with severe dengue development. Here, we hypothesized that the relatively lower TLR2 and CD14 expression in mild dengue patients is due to the shedding of their soluble forms (sTLR2 and sCD14) and that these could be use

SUBMITTER: Upasani V 

PROVIDER: S-EPMC10320027 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature