MiEAA 2023: updates, new functional microRNA sets and improved enrichment visualizations.

ABSTRACT: MicroRNAs (miRNAs) are small non-coding RNAs that play a critical role in regulating diverse biological processes. Extracting functional insights from a list of miRNAs is challenging, as each miRNA can potentially interact with hundreds of genes. To address this challenge, we developed miEAA, a flexible and comprehensive miRNA enrichment analysis tool based on direct and indirect miRNA annotation. The latest release of miEAA includes a data warehouse of 19 miRNA repositories, covering 10 different organisms and 139 399 functional categories. We have added information on the cellular context of miRNAs, isomiRs, and high-confidence miRNAs to improve the accuracy of the results. We have also improved the representation of aggregated results, including interactive Upset plots to aid users in u

SUBMITTER: Aparicio-Puerta E 

PROVIDER: S-EPMC10320052 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature