Ontology highlight
ABSTRACT:
SUBMITTER: Qiu T
PROVIDER: S-EPMC10320061 | biostudies-literature | 2023 Jul
REPOSITORIES: biostudies-literature
Qiu Tianyi T Zhang Lu L Chen Zikun Z Wang Yuan Y Mao Tiantian T Wang Caicui C Cun Yewei Y Zheng Genhui G Yan Deyu D Zhou Mengdi M Tang Kailin K Cao Zhiwei Z
Nucleic acids research 20230701 W1
Identifying the exact epitope positions for a monoclonal antibody (mAb) is of critical importance yet highly challenging to the Ab design of biomedical research. Based on previous versions of SEPPA 3.0, we present SEPPA-mAb for the above purpose with high accuracy and low false positive rate (FPR), suitable for both experimental and modelled structures. In practice, SEPPA-mAb appended a fingerprints-based patch model to SEPPA 3.0, considering the structural and physic-chemical complementarity be ...[more]