ProAct: quantifying the differential activity of biological processes in tissues, cells, and user-defined contexts.

ABSTRACT: The distinct functions and phenotypes of human tissues and cells derive from the activity of biological processes that varies in a context-dependent manner. Here, we present the Process Activity (ProAct) webserver that estimates the preferential activity of biological processes in tissues, cells, and other contexts. Users can upload a differential gene expression matrix measured across contexts or cells, or use a built-in matrix of differential gene expression in 34 human tissues. Per context, ProAct associates gene ontology (GO) biological processes with estimated preferential activity scores, which are inferred from the input matrix. ProAct visualizes these scores across processes, contexts, and process-associated genes. ProAct also offers potential cell-type annotations for cell subsets

SUBMITTER: Sharon M 

PROVIDER: S-EPMC10320064 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature