DEPICTER2: a comprehensive webserver for intrinsic disorder and disorder function prediction.

ABSTRACT: Intrinsic disorder in proteins is relatively abundant in nature and essential for a broad spectrum of cellular functions. While disorder can be accurately predicted from protein sequences, as it was empirically demonstrated in recent community-organized assessments, it is rather challenging to collect and compile a comprehensive prediction that covers multiple disorder functions. To this end, we introduce the DEPICTER2 (DisorderEd PredictIon CenTER) webserver that offers convenient access to a curated collection of fast and accurate disorder and disorder function predictors. This server includes a state-of-the-art disorder predictor, flDPnn, and five modern methods that cover all currently predictable disorder functions: disordered linkers and protein, peptide, DNA, RNA and lipid binding.

SUBMITTER: Basu S 

PROVIDER: S-EPMC10320100 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature