STellaris: a web server for accurate spatial mapping of single cells based on spatial transcriptomics data.

ABSTRACT: Single-cell RNA sequencing (scRNA-seq) provides insights into gene expression heterogeneities in diverse cell types underlying homeostasis, development and pathological states. However, the loss of spatial information hinders its applications in deciphering spatially related features, such as cell-cell interactions in a spatial context. Here, we present STellaris (https://spatial.rhesusbase.com), a web server aimed to rapidly assign spatial information to scRNA-seq data based on their transcriptomic similarity with public spatial transcriptomics (ST) data. STellaris is founded on 101 manually curated ST datasets comprising 823 sections across different organs, developmental stages and pathological states from humans and mice. STellaris accepts raw count matrix and cell type annotation of s

SUBMITTER: Li X 

PROVIDER: S-EPMC10320151 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature