FuzPred: a web server for the sequence-based prediction of the context-dependent binding modes of proteins.

ABSTRACT: Proteins form complex interactions in the cellular environment to carry out their functions. They exhibit a wide range of binding modes depending on the cellular conditions, which result in a variety of ordered or disordered assemblies. To help rationalise the binding behavior of proteins, the FuzPred server predicts their sequence-based binding modes without specifying their binding partners. The binding mode defines whether the bound state is formed through a disorder-to-order transition resulting in a well-defined conformation, or through a disorder-to-disorder transition where the binding partners remain conformationally heterogeneous. To account for the context-dependent nature of the binding modes, the FuzPred method also estimates the multiplicity of binding modes, the likelihood of

SUBMITTER: Hatos A 

PROVIDER: S-EPMC10320189 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature