FLUXestimator: a webserver for predicting metabolic flux and variations using transcriptomics data.

ABSTRACT: Quantitative assessment of single cell fluxome is critical for understanding the metabolic heterogeneity in diseases. Unfortunately, laboratory-based single cell fluxomics is currently impractical, and the current computational tools for flux estimation are not designed for single cell-level prediction. Given the well-established link between transcriptomic and metabolomic profiles, leveraging single cell transcriptomics data to predict single cell fluxome is not only feasible but also an urgent task. In this study, we present FLUXestimator, an online platform for predicting metabolic fluxome and variations using single cell or general transcriptomics data of large sample-size. The FLUXestimator webserver implements a recently developed unsupervised approach called single cell flux estimat

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC10320190 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature