Inhibition of Soluble Stem Cell Factor Promotes Intestinal Mucosal Repair.

ABSTRACT:

Background

Incidences of inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, are escalating worldwide and can be considered a global public health problem. Given that the gold standard approach to IBD therapeutics focuses on reducing the severity of symptoms, there is an urgent unmet need to develop alternative therapies that halt not only inflammatory processes but also promote mucosal repair. Previous studies have identified increased stem cell factor (SCF) expression in inflamed intestinal mucosal tissues. However, the role that SCF plays in mediating intestinal inflammation and repair has not been explored.

Methods

Changes in the expression of SCF were evaluated in the colonic tissue of healthy mice and during dextran sodium sulfate (DSS)-

SUBMITTER: Garcia-Hernandez V 

PROVIDER: S-EPMC10320368 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature