Towards a better understanding of arterial calcification disease progression in CKD: investigation of early pathological alterations.

ABSTRACT:

Background

Cardiovascular disease remains the leading cause of death in chronic kidney disease (CKD) patients, especially in those undergoing dialysis and kidney transplant surgery. CKD patients are at high risk of developing arterial media calcifications (AMC) and arterial stiffness. We hypothesized that investigation of disease progression at an early stage could provide novel insights in understanding AMC etiology.

Methods

An adenine diet was administered to male Wistar rats to induce AMC. Rats were sacrificed after 2, 4 and 8 weeks. AMC was measured by assessment of aortic calcium and visualized using histology. Arterial stiffness was measured in vivo by ultrasound and ex vivo by applying cyclic stretch of physiological magnitude on isolated arterial segments, allowing u

SUBMITTER: Van den Bergh G 

PROVIDER: S-EPMC10320369 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature