Microbial Dynamics in Newly Diagnosed and Treatment Naive IBD Patients in the Mediterranean.

ABSTRACT:

Background

Microbial communities have long been suspected to influence inflammatory processes in the gastrointestinal tract of patients with inflammatory bowel disease. However, these effects are often influenced by treatments and can rarely be analyzed in treatment-naïve onset cases. Specifically, microbial differences between IBD pathologies in new onset cases have rarely been investigated and can provide novel insight into the dynamics of the microbiota in Crohn's disease (CD) and ulcerative colitis (UC).

Methods

Fifty-six treatment-naïve IBD onset patients (67.3% CD, 32.7% UC) and 97 healthy controls were recruited from the Maltese population. Stool samples were collected after diagnosis but before administration of anti-inflammatory treatments. Fecal microbial communiti

SUBMITTER: Rausch P 

PROVIDER: S-EPMC10320370 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature