Identifying potential risk genes and pathways for neuropsychiatric and substance use disorders using intermediate molecular mediator information.

ABSTRACT: Neuropsychiatric and substance use disorders (NPSUDs) have a complex etiology that includes environmental and polygenic risk factors with significant cross-trait genetic correlations. Genome-wide association studies (GWAS) of NPSUDs yield numerous association signals. However, for most of these regions, we do not yet have a firm understanding of either the specific risk variants or the effects of these variants. Post-GWAS methods allow researchers to use GWAS summary statistics and molecular mediators (transcript, protein, and methylation abundances) infer the effect of these mediators on risk for disorders. One group of post-GWAS approaches is commonly referred to as transcriptome/proteome/methylome-wide association studies, which are abbreviated as T/P/MWAS (or collectively as XWAS). Sin

SUBMITTER: Gedik H 

PROVIDER: S-EPMC10320396 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature