Extracellular Acidification Augments NLRP3-Mediated Inflammasome Signaling in Macrophages.

ABSTRACT: Inflammation is a series of host defense processes in response to microbial infection and tissue injury. Inflammatory processes frequently cause extracellular acidification in the inflamed region through increased glycolysis and lactate secretion. Therefore, the immune cells infiltrating the inflamed region encounter an acidic microenvironment. Extracellular acidosis can modulate the innate immune response of macrophages; however, its role for inflammasome signaling still remains elusive. In the present study, we demonstrated that macrophages exposed to an acidic microenvironment exhibited enhanced caspase-1 processing and IL-1β secretion compared with those under physiological pH. Moreover, exposure to an acidic pH increased the ability of macrophages to assemble the NLR family pyrin doma

SUBMITTER: Chae BJ 

PROVIDER: S-EPMC10320421 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature