TNF ΔARE Pigs: A Translational Crohn's Disease Model.

ABSTRACT:

Background and aims

Crohn's disease [CD] is a major subtype of inflammatory bowel diseases [IBD] with increasing incidence and prevalence. Results of studies using available small and large animal models are often poorly translatable to patients, and few CD models show small intestinal pathology. Due to its similarities to humans, the pig has emerged as a highly suitable translational disease model, particularly for testing novel nutritional and technological interventions. Our goal was to develop a physiologically relevant porcine CD model to facilitate translation of findings and interventions towards the clinic.

Methods

We generated pigs bearing a 93-bp deletion of the adenosine-uracil-rich element [ARE] and a constitutive-decay element within the 3' untranslated region o

SUBMITTER: Winogrodzki T 

PROVIDER: S-EPMC10320488 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature