Endothelial tissue remodeling induced by intraluminal pressure enhances paracellular solute transport.

ABSTRACT: The endothelial layers of the microvasculature regulate the transport of solutes to the surrounding tissues. It remains unclear how this barrier function is affected by blood flow-induced intraluminal pressure. Using a 3D microvessel model, we compare the transport of macromolecules through endothelial tissues at mechanical rest or with intraluminal pressure, and correlate these data with electron microscopy of endothelial junctions. On application of an intraluminal pressure of 100 Pa, we demonstrate that the flow through the tissue increases by 2.35 times. This increase is associated with a 25% expansion of microvessel diameter, which leads to tissue remodeling and thinning of the paracellular junctions. We recapitulate these data with the deformable monopore model, in which the increase

SUBMITTER: Cacheux J 

PROVIDER: S-EPMC10320514 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature