Behavioral analysis through the lifespan of disc1 mutant zebrafish identifies defects in sensorimotor transformation.

ABSTRACT: DISC1 is a genetic risk factor for multiple psychiatric disorders. Compared to the dozens of murine Disc1 models, there is a paucity of zebrafish disc1 models-an organism amenable to high-throughput experimentation. We conducted the longitudinal neurobehavioral analysis of disc1 mutant zebrafish across key stages of life. During early developmental stages, disc1 mutants exhibited abrogated behavioral responses to sensory stimuli across multiple testing platforms. Moreover, during exposure to an acoustic sensory stimulus, loss of disc1 resulted in the abnormal activation of neurons in the pallium, cerebellum, and tectum-anatomical sites involved in the integration of sensory perception and motor control. In adulthood, disc1 mutants exhibited

SUBMITTER: Pluimer BR 

PROVIDER: S-EPMC10320522 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature