Growth patterns in patients with mucopolysaccharidosis VII.

ABSTRACT:

Objective

This study assessed growth patterns in patients with mucopolysaccharidosis (MPS) VII before enzyme replacement therapy.

Methods

Height, weight, and body mass index (BMI) measurements and Z-scores from patients from three clinical studies were compared with those from CDC healthy population growth charts. Relationships with age/sex and history of non-immune hydrops fetalis (NIHF) were assessed by linear regression and ANOVA, respectively.

Results

Among 20 enrolled patients with MPS VII, height Z-scores were near normal until 1 year of age but declined thereafter, particularly among males. There was no consistent pattern in weight Z-score. BMI Z-scores were above normal and increased slightly with age among males and were slightly b

SUBMITTER: Montano AM 

PROVIDER: S-EPMC10320588 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature