Altered neurovascular coupling in patients with vascular cognitive impairment: a combined ASL-fMRI analysis.

ABSTRACT:

Background and objective

This study aims to examine the role of neurovascular coupling (NVC) in vascular cognitive impairment (VCI) by investigating the relationship between white matter lesion (WML) burden, NVC, and cognitive deficits. Additionally, we aim to explore the potential of NVC as a tool for understanding the neural mechanisms underlying VCI.

Methods

This study included thirty-eight small vessel disease cognitive impairment (SVCI) patients, 34 post-stroke cognitive impairment (PSCI) patients, and 43 healthy controls (HC). Comprehensive assessments, including neuroimaging and neuropsychological testing, were conducted to evaluate cognitive function. WML burden was measured and correlated with NVC coefficients to examine the relationship between white matter patholo

SUBMITTER: Ruan Z 

PROVIDER: S-EPMC10320594 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature