Long-read genome assembly and gene model annotations for the rodent malaria parasite Plasmodium yoelii 17XNL.

ABSTRACT: Malaria causes >600 thousand fatalities each year, with most cases attributed to the human-infectious Plasmodium falciparum species. Many rodent-infectious Plasmodium species, like Plasmodium berghei and Plasmodium yoelii, have been used as model species that can expedite studies of this pathogen. P. yoelii is an especially good model for investigating the mosquito and liver stages of development because key attributes closely resemble those of P. falciparum. Because of its importance, in 2002 the 17XNL strain of P. yoelii was the first rodent malaria parasite to be sequenced. Although this was a breakthrough effort, the assembly consisted of >5000 contiguous sequences that adversely impacted the annotated gene models. While other rodent malaria parasite genomes have been sequenced and ann

SUBMITTER: Godin MJ 

PROVIDER: S-EPMC10320607 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature