The C. elegans gene gvd-1 promotes late larval development and germ cell proliferation.

ABSTRACT: Limiting maternal resources necessitates deferring the development of adult-specific structures, notably the reproductive structures, to the postembryonic phase. These structures form postembryonically from blast cells generated during embryogenesis. A close coordination of developmental timing and pattern among the various postembryonic cell lineages is essential to form a functional adult. Here, we show that the C. elegans gene gvd-1 is essential for the development of several structures that form during the late larval stages. In gvd-1 mutant animals, blast cells that normally divide during the late larval stages (L3 and L4) fail to divide. In addition, germ cell proliferation is also severely reduced in these animals. Expression patterns of relevant reporter transgenes revealed a delay

SUBMITTER: Ezhil Buvani AP 

PROVIDER: S-EPMC10320718 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature