GCPBayes pipeline: a tool for exploring pleiotropy at the gene level.

ABSTRACT: Cross-phenotype association using gene-set analysis can help to detect pleiotropic genes and inform about common mechanisms between diseases. Although there are an increasing number of statistical methods for exploring pleiotropy, there is a lack of proper pipelines to apply gene-set analysis in this context and using genome-scale data in a reasonable running time. We designed a user-friendly pipeline to perform cross-phenotype gene-set analysis between two traits using GCPBayes, a method developed by our team. All analyses could be performed automatically by calling for different scripts in a simple way (using a Shiny app, Bash or R script). A Shiny application was also developed to create different plots to visualize outputs from GCPBayes. Finally, a comprehensive and step-by-step tutori

SUBMITTER: Asgari Y 

PROVIDER: S-EPMC10320750 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature