The multivalent G-quadruplex (G4)-ligands MultiTASQs allow for versatile click chemistry-based investigations.

ABSTRACT: Chemical biology hinges on multivalent molecular tools that can specifically interrogate and/or manipulate cellular circuitries from the inside. The success of many of these approaches relies on molecular tools that make it possible to visualize biological targets in cells and then isolate them for identification purposes. To this end, click chemistry has become in just a few years a vital tool in offering practically convenient solutions to address highly complicated biological questions. We report here on two clickable molecular tools, the biomimetic G-quadruplex (G4) ligands MultiTASQ and ^azMultiTASQ, which benefit from the versatility of two types of bioorthogonal chemistry, CuAAC and SPAAC (the discovery of which was very recently awarded the Nobel Prize of chemistry). Thes

SUBMITTER: Rota Sperti F 

PROVIDER: S-EPMC10320843 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature