UV light-induced spatial loss of sialic acid capping using a photoactivatable sialyltransferase inhibitor.

ABSTRACT: Sialic acids cap glycans displayed on mammalian glycoproteins and glycolipids and mediate many glycan-receptor interactions. Sialoglycans play a role in diseases such as cancer and infections where they facilitate immune evasion and metastasis or serve as cellular receptors for viruses, respectively. Strategies that specifically interfere with cellular sialoglycan biosynthesis, such as sialic acid mimetics that act as metabolic sialyltransferase inhibitors, enable research into the diverse biological functions of sialoglycans. Sialylation inhibitors are also emerging as potential therapeutics for cancer, infection, and other diseases. However, sialoglycans serve many important biological functions and systemic inhibition of sialoglycan biosynthesis can have adverse effects. To enable local

SUBMITTER: Moons SJ 

PROVIDER: S-EPMC10320844 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature