Systemic inflammation index, disease severity, and mortality in patients with COVID-19: a systematic review and meta-analysis.

ABSTRACT:

Introduction

An excessive systemic pro-inflammatory state increases the risk of severe disease and mortality in patients with coronavirus disease 2019 (COVID-19). However, there is uncertainty regarding whether specific biomarkers of inflammation can enhance risk stratification in this group. We conducted a systematic review and meta-analysis to investigate an emerging biomarker of systemic inflammation derived from routine hematological parameters, the systemic inflammation index (SII), in COVID-19 patients with different disease severity and survival status.

Methods

A systematic literature search was conducted in PubMed, Web of Science, and Scopus, between the 1^st of December 2019 and the 15^th of March 2023. Risk of bias and certainty of evidence were

SUBMITTER: Mangoni AA 

PROVIDER: S-EPMC10320859 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature