A targeted metabolomics approach for sepsis-induced ARDS and its subphenotypes.

ABSTRACT:

Background

Acute respiratory distress syndrome (ARDS) is etiologically and clinically a heterogeneous disease. Its diagnostic characteristics and subtype classification, and the application of these features to treatment, have been of considerable interest. Metabolomics is becoming important for identifying ARDS biology and distinguishing its subtypes. This study aimed to identify metabolites that could distinguish sepsis-induced ARDS patients from non-ARDS controls, using a targeted metabolomics approach, and to identify whether sepsis-induced direct and sepsis-induced indirect ARDS are metabolically distinct groups, and if so, confirm their metabolites and associated pathways.

Methods

This study retrospectively analyzed 54 samples of ARDS patients from a sepsis registry th

SUBMITTER: Chang Y 

PROVIDER: S-EPMC10320874 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature